Introduction to Mesothelioma


Mesothelioma is one of the deadliest diseases known to man; the average life span of an inflicted person from the time of diagnosis until death is less than 24 months. It’s a disease that strikes approximately 3,000 United States citizens each and every year; hard working people who have labored for a lifetime to provide for their families, doing the work that keeps this country running and a great place to live. They worked in factories, at shipyards, in mines, for the US military, as engineers, as pipefitters, as steel workers, as auto mechanics, and in so many other professions.

Mesothelioma is a rare and virulent form of cancer that affects the lining of the lung, lining of the abdominal cavity or lining around the heart. Mesothelioma is caused by exposure to asbestos, and occurs in those who have breathed in asbestos fiber, in many cases 20 to 50 or more years ago. Some were exposed on their jobs; others were exposed secondarily through family members who without their knowledge, brought fiber home on their work clothes or on their hair or skin.

Despite the serious nature of the disease, there is hope. Every year, doctors and scientists worldwide are developing new treatments and making new discoveries that help to improve the chance of survival and the patient’s quality of life. This website, Beat Mesothelioma, helps patients and their family members connect with the resources they need to be informed and make the best decisions on their potential treatment and care.

 

The first section of our website answers common questions about Mesothelioma and its cause and discusses those at risk. In the next section, the most common symptoms are discussed, as well as the various testing procedures which may be used to come to a diagnosis. The treatment section discusses types of aggressive treatment such as surgery, chemotherapy, radiation and clinical trials being conducted by cancer facilities throughout the world, as well as the palliative care option for those who either can not or choose not to be treated. Every year, progress is being made.

 
Beat Mesothelioma is a site created to provide you with up to date information on the deadly disease Mesothelioma. We endeavour to provide the most complete overview of the disease and all aspects of it. This includes general information on the disease, breaking news on the search for a cure and perspective legislation designed to limit you as well as all other news on the subject, links to other sites and online resources that can provide important and in-depth Mesothelioma and cancer related information, and a legal guide to help you with the complex legal issues involved with Mesothelioma.

Mesothelioma is a disease that is almost 100% preventable; the only known cause is via exposure to the deadly mineral Asbestos. It comes from inhaling the particles of dust as the asbestos degrades; eating away at the lining of your lungs and developing into a deadly cancer. Dust that was inhaled in clouds of white powder, dust that was carried home on the clothes of the men who built this country, dust that was cleaned from the clothes by the wives and children who supported their sole provider at home, dust that was packed around the heating systems in houses and offices and schools, dust that carried a deadly price; and dust made a fortune in blood money for the companies that produced it.

Unfortunately, the effects of asbestos on the human body were known to be deadly for years by the companies who employed the ‘greatest generation’ and made hundreds of millions, if not billions, of dollars off of their backs. But instead of taking the basic steps to solve the problem and save the lives of thousands of their workers, they chose to do nothing and continue to make a “healthy” profit with a “deadly”

product. Many even went so far as to hide the truth from their workers and their families. And because the normal latency period for Mesothelioma (The time from exposure until the patient falls ill) is 20 to 30 years, many got away with this for years. We are only now beginning to see the full effects of the disease, and feel the terrible outcry of the people against those who put profits before human lives to a degree that is simply unfathomable.

Alfacell Achieves Full Patient Enrollment Milestone


Press Release Source: Alfacell Corporation
BLOOMFIELD, N.J., Feb. 27 /PRNewswire-FirstCall/ — Alfacell Corporation (Nasdaq: ACEL – News) today announced that the full enrollment target of 316 patients has been reached for the international, confirmatory Phase IIIb registration trial evaluating ONCONASE® (ranpirnase), the Company’s lead investigational drug candidate, as a treatment for unresectable malignant mesothelioma (UMM).The Company has developed and managed one of the largest UMM clinical programs ever undertaken. Over 600 UMM patients have been enrolled in the ONCONASE UMM study, including newly-diagnosed and refractory patients treated with ONCONASE as a single agent and in combination with doxorubicin.”We are pleased to have achieved this important milestone ahead of schedule, and look forward to completion of all other regulatory requirements for the marketing approval of ONCONASE in the U.S., E.U. and other markets,” stated Kuslima Shogen, Chief Executive Officer of Alfacell.

About the ONCONASE Phase IIIb Registration Study
ONCONASE is being evaluated at over 40 investigator sites across 10 countries in a centrally-randomized, open-label Phase IIIb trial as a treatment for UMM, an asbestos-related cancer that afflicts approximately 10,000 people worldwide — including 4,000 in the U.S. — each year. The study is being conducted to determine whether survival is prolonged in UMM patients treated with ONCONASE in combination with doxorubicin compared to doxorubicin alone. The estimated global UMM market is $300 million.

About ONCONASE
ONCONASE is a first-in-class therapeutic from Alfacell’s proprietary ribonuclease (RNase) technology platform. ONCONASE has been shown to target tumor cells while sparing normal cells. ONCONASE is internalized by endocytosis and released into the cytosol of the cancerous cell, where it selectively degrades tRNA beyond repair. In doing so, ONCONASE inhibits protein synthesis, stops cell cycle proliferation, and induces apoptosis (programmed cell death).ONCONASE has previously been granted Orphan Drug designation from EMEA and TGA (Australia), as well as Fast Track status by the FDA. The latter has enabled the Company to complete and submit sections of the New Drug Application (NDA) on an accelerated, rolling basis.In addition to the Phase IIIb UMM registration trial, the Company is conducting an ONCONASE Phase I / II trial in Non-Small Cell Lung Cancer (NSCLC). The NSCLC market is expected to exceed $4 billion by 2012.Also, pre-clinical studies examining ONCONASE conjugates as potential treatments for gliomas and Non-Hodgkins Lymphoma (NHL) are being conducted at Johns Hopkins University and the National Cancer Institute (NCI), respectively.

A brief overview of Mesothelioma cancer

Mesothelioma is a type of cancer that is found usually among men who are advanced in years. This type of cancer is caused from the effects of exposure to asbestos ad as a result affects the membranes of our vital organs such as the heart and lungs. Mesothelioma cancer is not very easy to diagnose due to the fact that the symptoms this type of cancer presents are very similar to other diseases that are much more common.

Pleural Mesothelioma

Pleural Mesothelioma is the most common form of this disease and as a direct result accounts for around 75% of all cases of this disease. This type of cancer (Pleural Mesothelioma) attacks and affects the lining of the lungs and presents common symptoms such as shortness of breath, coughing and wheezing, chest pains, difficulty in swallowing and even weight loss. As we have said, these symptoms are very common to other diseases but anyone who has any of them we would strongly suggest consulting their doctor right away just to be on the safe side.

Peritoneal Mesothelioma

One of the less common forms of Mesothelioma is called Peritoneal Mesothelioma and this type of cancer affects the abdomen. Peritoneal Mesothelioma cancer affects the abdominal lining and frequently found in people who have been exposed to asbestos and accounts for around 20% of all Mesothelioma cases. Symptoms of Peritoneal Mesothelioma are as follows: abdominal pains, abdominal swelling, weight loss, loss of appetite, weakness and nausea.

People who have worked with asbestos or have been exposed to the substance are at risk of developing the disease. One of the most important things that we should remember when dealing with this type of cancer is speed. Early diagnosis of the disease is of utmost importance so that it can be treated quickly. With time being of importance when dealing with Mesothelioma, the earlier it is discovered the more chance we have of success in its treatment.